TARGETED TGF BETA INHIBITION
This invention relates generally to bifunctional molecules including (a) a TGFβRII or fragment thereof capable of binding TGFβ and (b) an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1), uses of such molecules (e.g....
Saved in:
Main Author | |
---|---|
Format | Patent |
Language | English French German |
Published |
21.12.2016
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | This invention relates generally to bifunctional molecules including (a) a TGFβRII or fragment thereof capable of binding TGFβ and (b) an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1), uses of such molecules (e.g., for treating cancer), and methods of making such molecules. |
---|---|
AbstractList | This invention relates generally to bifunctional molecules including (a) a TGFβRII or fragment thereof capable of binding TGFβ and (b) an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1), uses of such molecules (e.g., for treating cancer), and methods of making such molecules. |
Author | LO, Kin-Ming |
Author_xml | – fullname: LO, Kin-Ming |
BookMark | eNrjYmDJy89L5WSQCXEMcncNcXVRCHF3U3ByDXFU8PTz8HTyDPH09-NhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAcaGBqZGJmaORsZEKAEA8VMh7w |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | INHIBITION CIBLEE DE FACTEUR DE CROISSANCE DE TRANSFORMATION BÊTA (TGF ) GEZIELTE TGF-BETA-HEMMUNG |
ExternalDocumentID | EP3105246A2 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_EP3105246A23 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 12:48:23 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English French German |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_EP3105246A23 |
Notes | Application Number: EP20150717097 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161221&DB=EPODOC&CC=EP&NR=3105246A2 |
ParticipantIDs | epo_espacenet_EP3105246A2 |
PublicationCentury | 2000 |
PublicationDate | 20161221 |
PublicationDateYYYYMMDD | 2016-12-21 |
PublicationDate_xml | – month: 12 year: 2016 text: 20161221 day: 21 |
PublicationDecade | 2010 |
PublicationYear | 2016 |
RelatedCompanies | Merck Patent GmbH |
RelatedCompanies_xml | – name: Merck Patent GmbH |
Score | 3.057324 |
Snippet | This invention relates generally to bifunctional molecules including (a) a TGFβRII or fragment thereof capable of binding TGFβ and (b) an antibody, or antigen... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
Title | TARGETED TGF BETA INHIBITION |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161221&DB=EPODOC&locale=&CC=EP&NR=3105246A2 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5KFfWmVbG2Sg6SW9C8NsmhSB6bJkLTUKL0VtzNFnqpxUb8-51d0upFb8Mu7GNgvnnuLMCDjya0IL5rLEngGQ4TiIMIlkbNeW0_cSJ8ITO6k4Jkr87L3J13YLV_C6P6hH6r5ogoURzlvVF4vfkJYiWqtnL7yFY49PGcVqNEb71jNF8sy9STaETLaTKN9ThGSi9mMo7tWg4JEa2PpBUt2-zTt0g-Stn81ijpORyXuNi6uYCOWPfgNN5_vNaDk0mb70ayFb3tJQyrcDamiDNaNU61iFahlhdZHuUyxnQFWkqrODNwm8XhSgtaHg5kX0MXPX1xA5qHvhB3BYLUu3BqnwXc4sxE_plL4dkB6UP_z2Vu_5kbwJnkjazCsMwhdJvPL3GHurRh94oLOzhxdKQ |
link.rule.ids | 230,309,786,891,25594,76906 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5KFetNq2K1ag6SW9C8NsmhSJ5NtElDWaW3YDZb6KUtNuLfdzak1Yvehl3Yx8B889xZgHsbTWhObFNZEMdSjJIjDiJYKhVjlf7ICLe5yOimGYlfjee5Oe_AcvcWpukT-tU0R0SJYijvdYPXm58gVtDUVm4fyiUOrZ8iOgrk1jtG80XTVDnwRmE-Daa-7PtIydlMxLFNzSAuovWBJZrzCsvpzROPUja_NUp0Aoc5LraqT6HDV33o-buP1_pwlLb5biRb0duewZC6s3GIOCPRcSR5IXWlJIsTLxExpnOQopD6sYLbFPsrFWG-P5B-AV309PklSBb6QszkCFLv3Kjs0mEaK1Xkn7rglu6QAQz-XObqn7k76MU0nRSTJHu5hmPBJ1GRoalD6NYfn_wG9Wpd3jYc-QbUn3eR |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=TARGETED+TGF+BETA+INHIBITION&rft.inventor=LO%2C+Kin-Ming&rft.date=2016-12-21&rft.externalDBID=A2&rft.externalDocID=EP3105246A2 |