CYCLIC SULFONE AND SULFOXIMINE ANALOGS AND USES THEREOF

• Main Authors: YANG, Hanbiao, XU, Rui, DIXON, Darryl David, GRINA, Jonas, WANG, Bin, WEHN, Paul, JOSEY, John A, RIZZI, James P, WALLACE, Eli M, SCHLACHTER, Stephen T
• Format: Patent
• Language: English; French; German
• Published: 29.05.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to cyclic sulfones and sulfoximines that are HIF-2a inhibitors and methods of making and using them for treating cancers. In another aspect, the present disclosure provides a pharmaceutical composition comprising a compound described herein and a pharmaceutically accep...