INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

• Main Authors: DING, Fa-Xiang, DONG, Shuzhi, JIANG, Jinlong, PIO, Barbara, CHOBANIAN, Harry, WALSH, Shawn, P, KIM, Dooseop, GUO, Yan
• Format: Patent
• Language: English; French; German
• Published: 07.08.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions incl...