METHOD FOR PRODUCING MEGAKARYOCYTES AND PLATELETS

• Main Authors: REAL LUNA, Pedro José, NAVARRO MONTERO, Óscar, BUENO UROZ, Clara, ROMERO ESCOBAR, Tamara, GARCÍA TOSCANO, Miguel, RAMOS MEJÍA, Verónica, MENÉNDEZ BUJAN, Pablo, AYLLÓN CASES, Verónica, COBO PULIDO, Marién, MARTÍN MOLINA, Francisco
• Format: Patent
• Language: English; French; German
• Published: 03.05.2017
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention is based on the surprising discovery that the overexpression of the SCL gene, having nucleotide sequence SEQ ID NO: 1, increases the production of megakaryocytes and platelets from stem cells. It has therefore been proven that this increase also occurs using PSCs which, unlike...