METHOD FOR PRODUCING MEGAKARYOCYTES AND PLATELETS

The present invention is based on the surprising discovery that the overexpression of the SCL gene, having nucleotide sequence SEQ ID NO: 1, increases the production of megakaryocytes and platelets from stem cells. It has therefore been proven that this increase also occurs using PSCs which, unlike...

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Main Authors REAL LUNA, Pedro José, NAVARRO MONTERO, Óscar, BUENO UROZ, Clara, ROMERO ESCOBAR, Tamara, GARCÍA TOSCANO, Miguel, RAMOS MEJÍA, Verónica, MENÉNDEZ BUJAN, Pablo, AYLLÓN CASES, Verónica, COBO PULIDO, Marién, MARTÍN MOLINA, Francisco
Format Patent
LanguageEnglish
French
German
Published 03.05.2017
Subjects
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention is based on the surprising discovery that the overexpression of the SCL gene, having nucleotide sequence SEQ ID NO: 1, increases the production of megakaryocytes and platelets from stem cells. It has therefore been proven that this increase also occurs using PSCs which, unlike CD34+ HSC cells which have limited expansion capacity, are characterized by an unlimited growth capacity, and can result in the unlimited production of platelets for clinical use.
Bibliography:Application Number: EP20140855992