THERMOSTABLE RESPIRATORY SYNCTIAL VIRUS (RSV) VACCINE COMPOSITIONS
Methods for improving the drying yield and stability of RSV vaccines comprising a highly thermolabile enveloped live virus and/or one or more RSV protein subunits, are described. Methods for rapid drying of RSV formulations containing between 17.5% and 60% w/w of a non-polymeric sugar and using eith...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French German |
| Published |
24.08.2016
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Methods for improving the drying yield and stability of RSV vaccines comprising a highly thermolabile enveloped live virus and/or one or more RSV protein subunits, are described. Methods for rapid drying of RSV formulations containing between 17.5% and 60% w/w of a non-polymeric sugar and using either conduction or radiation dominant drying mechanisms, are disclosed. The disclosed methods provide for; 1) a dried RSV formulation with improved stability profile; 2) faster drying; and 3) integration of dried RSV into a primary device (such as dual chamber cartridges, foil-pouch devices etc.), pre- as well as post-drying. |
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| AbstractList | Methods for improving the drying yield and stability of RSV vaccines comprising a highly thermolabile enveloped live virus and/or one or more RSV protein subunits, are described. Methods for rapid drying of RSV formulations containing between 17.5% and 60% w/w of a non-polymeric sugar and using either conduction or radiation dominant drying mechanisms, are disclosed. The disclosed methods provide for; 1) a dried RSV formulation with improved stability profile; 2) faster drying; and 3) integration of dried RSV into a primary device (such as dual chamber cartridges, foil-pouch devices etc.), pre- as well as post-drying. |
| Author | BHAMBHANI, AKHILESH EVANS, ROBERT, K ISOPI, LYNNE, A |
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| DocumentTitleAlternate | THERMOSTABILE RSV-IMPFSTOFFZUSAMMENSETZUNGEN COMPOSITIONS DE VACCINS THERMOSTABLES CONTRE LE VIRUS RESPIRATOIRE SYNCYTIAL (RSV) |
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| RelatedCompanies | MERCK SHARP & DOHME CORP |
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| Snippet | Methods for improving the drying yield and stability of RSV vaccines comprising a highly thermolabile enveloped live virus and/or one or more RSV protein... |
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| Title | THERMOSTABLE RESPIRATORY SYNCTIAL VIRUS (RSV) VACCINE COMPOSITIONS |
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