DRUG-CONJUGATES WITH A TARGETING MOLECULE AND TWO DIFFERENT DRUGS

There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second...

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Main Authors CHUCHOLOWSKI, Alexander, MIAO, Zhenwei, ZHU, Tong, ZHANG, Hong, KHASANOV, Alisher B, HONG, Yufeng, CHEN, Gang
Format Patent
LanguageEnglish
French
German
Published 22.09.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.
AbstractList There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.
Author MIAO, Zhenwei
HONG, Yufeng
CHUCHOLOWSKI, Alexander
ZHU, Tong
CHEN, Gang
KHASANOV, Alisher B
ZHANG, Hong
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– fullname: HONG, Yufeng
– fullname: CHEN, Gang
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DocumentTitleAlternate WIRKSTOFFKONJUGATE MIT EINEM ZIELMOLEKÜL UND ZWEI VERSCHIEDENEN WIRKSTOFFEN
CONJUGUÉS DE MÉDICAMENT COMPORTANT UNE MOLÉCULE DE CIBLAGE ET DEUX MÉDICAMENTS DIFFÉRENTS
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RelatedCompanies Sorrento Therapeutics, Inc
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Snippet There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title DRUG-CONJUGATES WITH A TARGETING MOLECULE AND TWO DIFFERENT DRUGS
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