MODIFIED SINGLE VARIABLE DOMAIN ANTIBODIES WITH REDUCED BINDING TO ANTI-DRUG-ANTIBODIES

• Main Authors: ASHMAN, CLAIRE, HOLLAND, CLAIRE, LEWIS, ALAN PETER, DE WILDT, RUDOLF M.T, MORLEY, PETER, SANDAL, THOMAS, STEWARD, MICHAEL, BIRCHLER, MARY
• Format: Patent
• Language: English; French; German
• Published: 13.07.2016
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions a...