HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I for use in oral dosage forms: Also provided are oral dosage forms comprising these compounds, methods of using the compou...

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Main Authors KALLAN, NICHOLAS, C, CHABOT, CHRISTINE, ZHANG, BIRONG, MITCHELL, IAN, S, DO, STEVEN, LIANG, JUN, XIAO, DENGMING, XU, RUI, SPENCER, KEITH, LEE, SCHLACHTER, STEPHEN, T, BENCSIK, JOSEF, R, BLAKE, JAMES, F, BANKA, ANNA, L, WALLACE, ELI, W, SAFINA, BRIAN
Format Patent
LanguageEnglish
French
German
Published 02.03.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I for use in oral dosage forms: Also provided are oral dosage forms comprising these compounds, methods of using the compounds and oral dosage forms of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer. Further provided are intermediate compounds from the synthesis of these compounds.
AbstractList The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I for use in oral dosage forms: Also provided are oral dosage forms comprising these compounds, methods of using the compounds and oral dosage forms of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer. Further provided are intermediate compounds from the synthesis of these compounds.
Author KALLAN, NICHOLAS, C
SAFINA, BRIAN
ZHANG, BIRONG
DO, STEVEN
WALLACE, ELI, W
MITCHELL, IAN, S
BENCSIK, JOSEF, R
BANKA, ANNA, L
SCHLACHTER, STEPHEN, T
LIANG, JUN
XIAO, DENGMING
CHABOT, CHRISTINE
XU, RUI
SPENCER, KEITH, LEE
BLAKE, JAMES, F
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– fullname: LIANG, JUN
– fullname: XIAO, DENGMING
– fullname: XU, RUI
– fullname: SPENCER, KEITH, LEE
– fullname: SCHLACHTER, STEPHEN, T
– fullname: BENCSIK, JOSEF, R
– fullname: BLAKE, JAMES, F
– fullname: BANKA, ANNA, L
– fullname: WALLACE, ELI, W
– fullname: SAFINA, BRIAN
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DocumentTitleAlternate PYRIMIDINES CYCLOPENTA [D] HYDROXYLÉES ET MÉTHOXYLÉES UTILISÉES EN TANT QU'INHIBITEURS DE LA PROTÉINE KINASE AKT
HYDROXYLIERTE UND METHOXYLIERTE CYCLOPENTA [D]-PYRIMIDINE ALS AKT-PROTEINKINASEHEMMER
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RelatedCompanies ARRAY BIOPHARMA, INC
GENENTECH, INC
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Snippet The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof,...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS
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