GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

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Main Authors BESKROVNAYA, Oxana, CELATKA, Cassandra, XIANG, Yibin, LEONARD, John, BOURQUE, Elyse, SKERLJ, Renato, MAKINO, Elina, METZ, Markus, NATOLI, Thomas, GOOD, Andrew, CABRERA-SALAZAR, Mario, A, HIRTH, Bradford, CHENG, Seng, H, SCHEULE, Ronald, K, HUSSON, Herve, MARSHALL, John, ZHAO, Zhong, JANCSICS, Katherine
Format Patent
LanguageEnglish
French
German
Published 23.02.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
AbstractList The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Author CHENG, Seng, H
LEONARD, John
XIANG, Yibin
NATOLI, Thomas
HIRTH, Bradford
CELATKA, Cassandra
JANCSICS, Katherine
GOOD, Andrew
SCHEULE, Ronald, K
MARSHALL, John
BOURQUE, Elyse
ZHAO, Zhong
MAKINO, Elina
SKERLJ, Renato
BESKROVNAYA, Oxana
METZ, Markus
CABRERA-SALAZAR, Mario, A
HUSSON, Herve
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– fullname: CELATKA, Cassandra
– fullname: XIANG, Yibin
– fullname: LEONARD, John
– fullname: BOURQUE, Elyse
– fullname: SKERLJ, Renato
– fullname: MAKINO, Elina
– fullname: METZ, Markus
– fullname: NATOLI, Thomas
– fullname: GOOD, Andrew
– fullname: CABRERA-SALAZAR, Mario, A
– fullname: HIRTH, Bradford
– fullname: CHENG, Seng, H
– fullname: SCHEULE, Ronald, K
– fullname: HUSSON, Herve
– fullname: MARSHALL, John
– fullname: ZHAO, Zhong
– fullname: JANCSICS, Katherine
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DocumentTitleAlternate GLUCOSYLCERAMID-SYNTHASE-HEMMER
INHIBITEURS DE SYNTHASE DE GLUCOSYLCÉRAMIDE
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Snippet The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
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