Cocrystals of raltegravir potassium

Novel solid forms of Raltegravir potassium comprising the active ingredient N-[2-[(4Z)-4-[[(4-fluorophenyl)methylamino]-hydroxymethylidene]-1-methyl-5,6-dioxopyrimidin-2-yl]propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide as potassium salt co-crystal with cyclamic acid, saccharin, stearic acid o...

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Main Authors VIERTELHAUS, MARTIN, WEISHAAR, WALTER, HAFNER, ANDREAS, SALVADOR, BEATE, CHIODO, TIZIANA, HINTERMANN, TOBIAS, VOSSEN, MARCUS
Format Patent
LanguageEnglish
French
German
Published 31.12.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Novel solid forms of Raltegravir potassium comprising the active ingredient N-[2-[(4Z)-4-[[(4-fluorophenyl)methylamino]-hydroxymethylidene]-1-methyl-5,6-dioxopyrimidin-2-yl]propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide as potassium salt co-crystal with cyclamic acid, saccharin, stearic acid or succinic acid. The multi-component crystalline forms show improved properties such as dissolution kinetic and hydration stability.
AbstractList Novel solid forms of Raltegravir potassium comprising the active ingredient N-[2-[(4Z)-4-[[(4-fluorophenyl)methylamino]-hydroxymethylidene]-1-methyl-5,6-dioxopyrimidin-2-yl]propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide as potassium salt co-crystal with cyclamic acid, saccharin, stearic acid or succinic acid. The multi-component crystalline forms show improved properties such as dissolution kinetic and hydration stability.
Author CHIODO, TIZIANA
WEISHAAR, WALTER
SALVADOR, BEATE
VOSSEN, MARCUS
VIERTELHAUS, MARTIN
HAFNER, ANDREAS
HINTERMANN, TOBIAS
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– fullname: CHIODO, TIZIANA
– fullname: HINTERMANN, TOBIAS
– fullname: VOSSEN, MARCUS
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DocumentTitleAlternate Co-cristaux de raltégravir potassium
Kokristalle von Raltegravir-Kalium
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Snippet Novel solid forms of Raltegravir potassium comprising the active ingredient...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Cocrystals of raltegravir potassium
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