TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER

The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient; (ii) an opioid antagonist and/or an aversive agent; (iii) a polyalkylene oxide having an average molecular weight of at...

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Main Authors BARTHOLOMÄUS, Johannes, SCHWIER, Sebastian, GEISSLER, Anja, BARNSCHEID, Lutz
Format Patent
LanguageEnglish
French
German
Published 03.04.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient; (ii) an opioid antagonist and/or an aversive agent; (iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol; and (a) further comprising (iv) an anionic polymer; and/or (b) having a storage stability at 40° C. of at least 3 months.
AbstractList The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient; (ii) an opioid antagonist and/or an aversive agent; (iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol; and (a) further comprising (iv) an anionic polymer; and/or (b) having a storage stability at 40° C. of at least 3 months.
Author BARNSCHEID, Lutz
BARTHOLOMÄUS, Johannes
GEISSLER, Anja
SCHWIER, Sebastian
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DocumentTitleAlternate FORME PHARMACEUTIQUE ORALE INVIOLABLE COMPORTANT UN AGENT PAHRMACOLOGIQUEMENT ACTIF, UN ANTAGONISTE OPIOÏDE OU AGENT DISSUASIF, UN OXYDE DE POLYALKYLÈNE ET UN POLYMÈRE ANIONIQUE
GEGEN MISSBRAUCH GESICHERTE ORALE PHARMAZEUTISCHE DOSISFORM, DIE EINEN PHARMAKOLOGISCH AKTIVEN WIRKSTOFF, EINEN OPIOID-ANTAGONISTEN ODER ABSCHRECKUNGSMITTEL, POLYALKYLENOXID UND EIN ANIONISCHES POLYMER UMFASST
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Snippet The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a...
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER
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