CELLS DEFICIENT IN CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE AND/OR GLYCOPROTEIN ALPHA-1,3-GALACTOSYLTRANSFERASE
The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of...
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| Main Authors | , , , , , |
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| Format | Patent |
| Language | English French German |
| Published |
12.08.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation. |
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| AbstractList | The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation. |
| Author | LIN, NAN ACHTIEN, KATHERINE GEORGE, HENRY J MASCARENHAS, JOAQUINA KAYSER, KEVIN J COLLINGWOOD, TREVOR N |
| Author_xml | – fullname: LIN, NAN – fullname: COLLINGWOOD, TREVOR N – fullname: MASCARENHAS, JOAQUINA – fullname: KAYSER, KEVIN J – fullname: ACHTIEN, KATHERINE – fullname: GEORGE, HENRY J |
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| DocumentTitleAlternate | CELLULES DÉFICIENTES EN ACIDE CMP-N-ACÉTYLNEURAMINIQUE HYDROXYLASE ET/OU EN GLYCOPROTÉINE ALPHA-1,3-GALACTOSYLTRANSFÉRASE ZELLEN MIT MANGEL AN CMP-N-ACETYLNEURAMINSÄURE-HYDROXYLASE UND/ODER GLYCOPROTEIN-ALPHA-1,3-GALACTOSYLTRANSFERASE |
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| RelatedCompanies | SIGMA-ALDRICH CO. LLC |
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| Snippet | The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMES ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | CELLS DEFICIENT IN CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE AND/OR GLYCOPROTEIN ALPHA-1,3-GALACTOSYLTRANSFERASE |
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