PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

• Main Authors: SEO, JEONGBEOB, CONDROSKI, KEVIN, R, JIANG, YUTONG, BLAKE, JAMES, F, HUANG, LILY, ALLEN, SHELLEY, ANDREWS, STEVEN, W, KOLAKOWSKI, GABRIELLE R, KERCHER, TIMOTHY, HAAS, JULIA
• Format: Patent
• Language: English; French; German
• Published: 02.04.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y-B moiety and the NH-C(═X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are use...