ENHANCED BIODISTRIBUTION OF OLIGOMERS
This invention relates generally to oligomers useful for modulating expression and/or activity of RNAs or genes. More particularly, the invention relates to single stranded, double stranded, partially double stranded and hairpin structured chemically modified oligomers that have a broad biodistribut...
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Main Author | |
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Format | Patent |
Language | English French German |
Published |
19.11.2014
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Subjects | |
Online Access | Get full text |
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Summary: | This invention relates generally to oligomers useful for modulating expression and/or activity of RNAs or genes. More particularly, the invention relates to single stranded, double stranded, partially double stranded and hairpin structured chemically modified oligomers that have a broad biodistribution profile for inhibiting RNA expression in a plurality of cells, tissues, or organs, and to methods of making and using the modified oligomers. |
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Bibliography: | Application Number: EP20120752665 |