METHOD OF PRODUCING INTESTINAL CELLS
An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (A) inducing differentiation of pluripoten...
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Format | Patent |
Language | English French German |
Published |
11.09.2013
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Abstract | An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (A) inducing differentiation of pluripotent stem cells into definitive endoderm cells; and (B) culturing the definitive endoderm cells in the presence of (2'Z, 3'E)-6-bromoindirubin-3-oxime (BIO) and N-[(3,5-difluorophenyl)acetyl]-L-Ala-2-phenyl-L-Gly-tert-butyl-OH (DAPT) to thereby induce differentiation of the definitive endoderm cells into intestinal cells. |
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AbstractList | An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (A) inducing differentiation of pluripotent stem cells into definitive endoderm cells; and (B) culturing the definitive endoderm cells in the presence of (2'Z, 3'E)-6-bromoindirubin-3-oxime (BIO) and N-[(3,5-difluorophenyl)acetyl]-L-Ala-2-phenyl-L-Gly-tert-butyl-OH (DAPT) to thereby induce differentiation of the definitive endoderm cells into intestinal cells. |
Author | KUME SHOEN KUME KAZUHIKO OGAKI SOICHIRO SHIRAKI NOBUAKI |
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Discipline | Medicine Chemistry Sciences Physics |
DocumentTitleAlternate | PROCÉDÉ DE PRODUCTION DE CELLULES INTESTINALES VERFAHREN ZUR HERSTELLUNG VON DARMZELLEN |
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RelatedCompanies | NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY |
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Snippet | An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to... |
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Title | METHOD OF PRODUCING INTESTINAL CELLS |
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