METHOD OF PRODUCING INTESTINAL CELLS
An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (A) inducing differentiation of pluripoten...
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Main Authors | , , , |
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Format | Patent |
Language | English French German |
Published |
11.09.2013
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Subjects | |
Online Access | Get full text |
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Summary: | An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (A) inducing differentiation of pluripotent stem cells into definitive endoderm cells; and (B) culturing the definitive endoderm cells in the presence of (2'Z, 3'E)-6-bromoindirubin-3-oxime (BIO) and N-[(3,5-difluorophenyl)acetyl]-L-Ala-2-phenyl-L-Gly-tert-butyl-OH (DAPT) to thereby induce differentiation of the definitive endoderm cells into intestinal cells. |
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Bibliography: | Application Number: EP20110837965 |