SINGLE CHAIN RELAXIN POLYPEPTIDES

The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are anta...

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Main Authors LAWRENCE, ANDREW, J, HAUGAARD-KEDSTROM, LINDA MARIA, HOSSAIN, MOHAMMED, AKHTER, BATHGATE, ROSS, ALEXANDER, DAVID, WADE, JOHN, DESMOND, GUNDLACH, ANDREW, LAWRENCE, ROSENGREN, KARL, JOHAN
Format Patent
LanguageEnglish
French
German
Published 26.10.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are antagonists of the RXFP3 receptor, and in some embodiments are selective antagonists of the RXFP3 receptor.
Bibliography:Application Number: EP20110822934