INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS

• Main Authors: LO, SIE-MUN, SHIPPS, GERALD, W., JR, MUPPALLA, KIRAN, DENG, YONGQI, COOPER, ALAN, B, ZHU, LIANG
• Format: Patent
• Language: English; French; German
• Published: 29.01.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a compound of the Formula I: Formula I or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, R4, X, m and n are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above co...