OLIGONUCLEOTIDE COMPOUNDS COMPRISING NON-NUCLEOTIDE OVERHANGS
The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutical...
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| Main Authors | , |
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| Format | Patent |
| Language | English French German |
| Published |
09.08.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the target genes and/or symptoms associated with such diseases or conditions. |
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| AbstractList | The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the target genes and/or symptoms associated with such diseases or conditions. |
| Author | AVKIN-NACHUM, Sharon FEINSTEIN, Elena |
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| DocumentTitleAlternate | COMPOSÉS OLIGONUCLÉOTIDIQUES COMPRENANT DES DÉBORDS NON NUCLÉOTIDIQUES OLIGONUKLEOTIDVERBINDUNGEN MIT NICHT-NUKLEODTID-ÜBERHÄNGEN |
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| Notes | Application Number: EP20110701706 |
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| PublicationDateYYYYMMDD | 2017-08-09 |
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| PublicationYear | 2017 |
| RelatedCompanies | Quark Pharmaceuticals, Inc |
| RelatedCompanies_xml | – name: Quark Pharmaceuticals, Inc |
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| Snippet | The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | OLIGONUCLEOTIDE COMPOUNDS COMPRISING NON-NUCLEOTIDE OVERHANGS |
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