IMPROVED PROCESS FOR PREPARATION OF CLOPIODOGREL BISULFATE CRYSTALLINE FORM-1

An improved process for preparing crystalline form-1 of (S)-methyl 2-(2-chlorophenyl)-2-{6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl}acetate bisulfate (clopidogrel bisulfate) of formula I is provided The preparation comprises the straight conversion of an uncyclized material of (S)-methyl 2-[2-(thioph...

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Main Authors RAMANA, VENKATA, P, BURGER, WOLFGANG, GUDAPARTHI, OMPRAKASH, REDDY, KONDA SRINIVASA, KUMAR, SUNEEL, K
Format Patent
LanguageEnglish
French
German
Published 29.08.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:An improved process for preparing crystalline form-1 of (S)-methyl 2-(2-chlorophenyl)-2-{6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl}acetate bisulfate (clopidogrel bisulfate) of formula I is provided The preparation comprises the straight conversion of an uncyclized material of (S)-methyl 2-[2-(thiophen-2-yl)ethylamino]-2-(2-chlorophenyl) acetate hydrochloride into clopidogrel bisulfate crystalline form-1 without any degradation of clopidogrel base
Bibliography:Application Number: EP20100828022