BLOCKING ANTI-DKK-1 ANTIBODIES AND THEIR USES

• Main Authors: PONS, JAUME, PARALKAR, VISHWAS MADHAV, STONE, DONNA MARIE, LI, MEI
• Format: Patent
• Language: English; French; German
• Published: 21.03.2012
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided...