Preparation of substituted carbonate and carbamate derivatives

The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate th...

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Main Authors NICHOLS, PAUL, J, PLATA, DANIEL, J, CONDON, STEPHEN, DEMATTEI, JOHN, J, MANNA, SUKUMAR, CHANG, SOU-JEN, KING, STEVEN, A, PATEL, HEMANT, H, ALLEN, MICHAEL, S, KOLACZKOWSKI, LAWRENCE, STONER, ERIC, J, PATEL, SUBHASH, R, WITTENBERGER, STEVEN, J, PREMCHANDRAN, RAMIYA, H, TIEN, JIEN-HEH, J
Format Patent
LanguageEnglish
French
German
Published 31.07.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)
Bibliography:Application Number: EP20110181256