Site-directed modification of FVIII

• Main Authors: PAN, CLARK Q, MURPHY, JOHN E, STRAUSS, JONATHAN S, TJANDRA, HENDRI, MEI, BAISONG, BARNETT, THOMAS, CHEN, JIANMIN, TANG, LIANG, WAMG, DEQIAN
• Format: Patent
• Language: English; French; German
• Published: 07.09.2011
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.