HSA-free formulations of interferon-beta
Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-²) and methods useful in their preparation are provided. The compositions comprise the IFN-² solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French German |
| Published |
16.02.2011
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-²) and methods useful in their preparation are provided. The compositions comprise the IFN-² solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-² in pharmaceutical compositions, are provided. |
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| AbstractList | Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-²) and methods useful in their preparation are provided. The compositions comprise the IFN-² solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-² in pharmaceutical compositions, are provided. |
| Author | TELLERS, MELANIE SHIRLEY, BRET CHOE, MINNA BABUKA, SUSAN |
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| DocumentTitleAlternate | HSA-frei Interferon-beta Formulierungen Formulation d'interférone beta ne contenant pas de HSA |
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| RelatedCompanies | NOVARTIS VACCINES AND DIAGNOSTICS, INC |
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| Snippet | Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-²) and methods useful in their preparation are provided. The... |
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| SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | HSA-free formulations of interferon-beta |
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