COMPOSITION AND METHOD FOR TREATMENT OF AUTOIMMUNE DISEASE

The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function as antagonists of Toll-like Receptor 2 are shown to suppress the immune response which result in the onset and progression of autoimmune dise...

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Main Authors MCGUIRK, PETER, KEOGH, BRIAN, LOCHER, CHRISTOPHER, O'NEILL, LUKE, HEFFERNAN, MARK
Format Patent
LanguageEnglish
French
German
Published 07.04.2010
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function as antagonists of Toll-like Receptor 2 are shown to suppress the immune response which result in the onset and progression of autoimmune disease. In particular monoclonal antibodies which have a binding specificity to Toll-like receptor 2 are disclosed for use in methods for the treatment and/or prophylaxis of autoimmune disease.
AbstractList The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function as antagonists of Toll-like Receptor 2 are shown to suppress the immune response which result in the onset and progression of autoimmune disease. In particular monoclonal antibodies which have a binding specificity to Toll-like receptor 2 are disclosed for use in methods for the treatment and/or prophylaxis of autoimmune disease.
Author KEOGH, BRIAN
LOCHER, CHRISTOPHER
MCGUIRK, PETER
HEFFERNAN, MARK
O'NEILL, LUKE
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DocumentTitleAlternate ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON AUTOIMMUNKRANKHEITEN
COMPOSITION ET PROCÉDÉ DE TRAITEMENT DE MALADIE AUTO-IMMUNE
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Snippet The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title COMPOSITION AND METHOD FOR TREATMENT OF AUTOIMMUNE DISEASE
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