MMP ACTIVATED VASCULAR DISRUPTING AGENTS

The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.

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Bibliographic Details
Main Authors PATTERSON, LAURENCE, ATKINSON, JENNIFER, FALCONER, ROB, GILL, JASON, LOADMAN, PAUL, BIBBY, MIKE
Format Patent
LanguageEnglish
French
German
Published 23.12.2009
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.
Bibliography:Application Number: EP20080718877