PROTEIN MICROSPHERES RETAINING PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES

The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhanc...

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Main Authors BROWN, LARRY R, YANG, MARK X, O'CONNELL, ED
Format Patent
LanguageEnglish
French
German
Published 12.08.2009
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Abstract The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical particles that are substantially amorphous or non-crystalline and are injectable through fine bore needles at high concentrations. The particles exhibit the pharmacokinetic and pharmacodynamnic properties of the active agent. The disclosure has special application for higher molecular weight proteins such as antibodies.
AbstractList The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical particles that are substantially amorphous or non-crystalline and are injectable through fine bore needles at high concentrations. The particles exhibit the pharmacokinetic and pharmacodynamnic properties of the active agent. The disclosure has special application for higher molecular weight proteins such as antibodies.
Author YANG, MARK X
BROWN, LARRY R
O'CONNELL, ED
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DocumentTitleAlternate MICROSPHÈRES DE PROTÉINES CONSERVANT DES PROPRIÉTÉS PHARMACOCINÉTIQUES ET PHARMACODYNAMIQUES
PROTEINMIKROKUGELN MIT PHARMAKOKINETISCHEN UND PHARMAKODYNAMISCHEN EIGENSCHAFTEN
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RelatedCompanies BAXTER INTERNATIONAL INC
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Snippet The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the...
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PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PROTEIN MICROSPHERES RETAINING PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES
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