RETROGRADE TRANSPORT OF SIRNA AND THERAPEUTIC USES TO TREAT NEUROLOGIC DISORDERS
Methods of treating disorders affecting the central nervous system (CNS) are disclosed. More particularly, methods of treating neurological disorders are disclosed which show therapeutic or prophylactic treatment of a mammalian CNS disorder by effecting local administration of an iRNA agent, followe...
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| Main Authors | , |
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| Format | Patent |
| Language | English French German |
| Published |
13.05.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Methods of treating disorders affecting the central nervous system (CNS) are disclosed. More particularly, methods of treating neurological disorders are disclosed which show therapeutic or prophylactic treatment of a mammalian CNS disorder by effecting local administration of an iRNA agent, followed by retrograde transport of the iRNA agent away from the administration site and onto multiple regions within the CNS. This retrograde transport of iRNA results in an improved therapeutic involvement for the respective iRNA agent. |
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| AbstractList | Methods of treating disorders affecting the central nervous system (CNS) are disclosed. More particularly, methods of treating neurological disorders are disclosed which show therapeutic or prophylactic treatment of a mammalian CNS disorder by effecting local administration of an iRNA agent, followed by retrograde transport of the iRNA agent away from the administration site and onto multiple regions within the CNS. This retrograde transport of iRNA results in an improved therapeutic involvement for the respective iRNA agent. |
| Author | SAH, DINAH STEWART, ROBERT, GREGORY |
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| DocumentTitleAlternate | TRANSPORT EN SENS RÉTROGRADE D'ARNSI ET UTILISATIONS THÉRAPEUTIQUES POUR TRAITER DES TROUBLES NEUROLOGIQUES RETROGRADER TRANSPORT VON SIRNA UND THERAPEUTISCHE VERWENDUNGEN ZUR BEHANDLUNG VON NEUROLOGISCHEN ERKRANKUNGEN |
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| RelatedCompanies | ALNYLAM PHARMACEUTICALS INC MEDTRONIC, INC |
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| Snippet | Methods of treating disorders affecting the central nervous system (CNS) are disclosed. More particularly, methods of treating neurological disorders are... |
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| SubjectTerms | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING |
| Title | RETROGRADE TRANSPORT OF SIRNA AND THERAPEUTIC USES TO TREAT NEUROLOGIC DISORDERS |
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