METHOD FOR PREPARING 4-[17BETA -METHOXY-17 -ALPHA METHOXYMETHYL-3-OXOESTRA-4,9-DIEN-11BETA -YL]BENZALDEHYDE (E)-OXIME (ASOPRISNIL)

The present invention relates to a method for the reliable and reproducible preparation of 4-[17ß-methoxy-17a-methoxymethyl-3-oxoestra-4,9-dien-llß- yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very g...

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Bibliographic Details
Main Authors VOIGTLAENDER, DAVID, MOSEBACH, MICHAEL, GERECKE, HAGEN, EILERS, ROBERT, KNABE, UWE, TILSTAM, ULF, JACKE, JUERGEN, GLIESING, SABINE, WEHMEIER, DIETER, BOHLMANN, ULF, MUELLER, UWE, HOESEL, PETER, MICHEL, THOMAS, BAHL, KLAUS, SANDER, MICHAEL, GRAWE, DETLEF, ERHART, BERND
Format Patent
LanguageEnglish
French
German
Published 07.01.2009
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The present invention relates to a method for the reliable and reproducible preparation of 4-[17ß-methoxy-17a-methoxymethyl-3-oxoestra-4,9-dien-llß- yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
Bibliography:Application Number: EP20070724653