BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES

• Main Authors: CAO, JIANGUO, HOOD, JOHN, MC PHERSON, ANDREW, SOLL, RICHARD, M, LOHSE, DANIEL, MAK, CHI, CHING, NORONHA, GLENN, RENICK, JOEL, PATHAK, VED, ZENG, BINQI
• Format: Patent
• Language: English; French; German
• Published: 13.07.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.