MONOCLONAL ANTI MINICHROMOSOME MAINTENANCE 2 PROTEIN ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE
Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of th...
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Format | Patent |
Language | English French German |
Published |
07.09.2011
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Abstract | Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the application are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the application are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present application. |
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AbstractList | Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the application are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the application are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present application. |
Author | FISCHER, TIMOTHY, J TAYLOR, ADRIANN, J MALINOWSKI, DOUGLAS, P |
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DocumentTitleAlternate | ANTICORPS MONOCLONAUX DIRIGES CONTRE LA PROTEINE DE LA MAINTENANCE DES MINICHROMOSOMES 2 ET LEURS MÉTHODES D'UTILISATION DANS LA DÉTECTION D'UNE MALADIE CERVICALE MONOKLONALE ANTI MINICHROMOSOME MAINTENANCE 2 PROTEIN ANTIKÖRPER UND VERFAHREN ZU DEREN VERWENDUNG BEIM NACHWEIS EINER ZERVIKALEN ERKRANKUNG |
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Notes | Application Number: EP20060758599 |
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Snippet | Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
Title | MONOCLONAL ANTI MINICHROMOSOME MAINTENANCE 2 PROTEIN ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE |
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