HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1

• Main Authors: FAROUZ, FRANCINE, S, STAPPENBECK, FRANK, KESICKI, EDWARD, A, THORSETT, EUGENE, DIAZ, FRANK, GAUDINO, JOHN, JOSEPH, RUDOLPH, ALEXANDER, HOLCOMB, RYAN, COOK, ADAM, WADE, OOI, HUA, CHEE, FISHER, KIMBA, L
• Format: Patent
• Language: English; French; German
• Published: 26.12.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA re...