BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES
Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dic...
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Format | Patent |
Language | English French German |
Published |
02.09.2009
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Abstract | Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy. |
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AbstractList | Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy. |
Author | OLDFIELD, ERIC CHAN, JULIAN M. W ZHANG, YONGHUI SANDERS, JOHN M SONG, YONGCHENG |
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DocumentTitleAlternate | BISPHOSPHONATVERBINDUNGEN UND -VERFAHREN FÜR KNOCHENSCHWUNDKRANKHEITEN, KREBS, KNOCHENSCHMERZEN, IMMUNSTÖRUNGEN UND INFEKTIONSKRANKHEITEN COMPOSES DE BISPHOSPHONATE ET METHODES DE TRAITEMENT DE MALADIES DE RESORPTION OSSEUSE, DE CANCERS, DE DOULEURS OSSEUSES, DE TROUBLES IMMUNITAIRES ET DE MALADIES INFECTIEUSES |
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Snippet | Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The... |
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Title | BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES |
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