5-SUBSTITUTED-2-PHENYLAMINO BENZAMIDES AS MEK INHIBITORS

• Main Authors: MATSUBARA, YASUAKI, SHIMMA, NOBUO, MIWA, MASANORI, TSUJII, SHINJI, AIDA, SATOSHI, KOHCHI, YASUNORI, KOHCHI, MASAMI, MIZUGUCHI, EISAKU, ISSHIKI, YOSHIAKI, IIKURA, HITOSHI, MURATA, TAKESHI, ASO, KOSUKE
• Format: Patent
• Language: English; French; German
• Published: 02.05.2007
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically accepta...