PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES

• Main Authors: LEROUX, FREDERIC, SCHLOSSER, MANFRED, METTLER, HANSPETER
• Format: Patent
• Language: English; French; German
• Published: 26.11.2008
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

A process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula: wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally being substituted with one or more halogen atoms, and R2 and R3 are equal and are C5-10-cycloalkyl and C1-6-alkyl, or R2 is C5-10-cycloalkyl or C1-6-alkyl, and R3 is aryl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, nitro, amino, C1-6-alkyl, C1-6-akoxy and di-C1-6-alkylamino groups,2 and each C1-6-alkyl, C1-6-alkoxy, di-C1-6-alkylamino and C5-10-cycloalkyl group in R2 and R3 is optionally substituted with one or more halogen atoms, from 2,2',6,6'-tetrabromobiphenyl by a sequence of bromine-metal exchanges and subsequent reactions.