PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES

A process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula: wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally being substituted with one or more halogen atoms, and R2 and R3 are equal and are C5-10-cycloalkyl and C1-6-alkyl, or R2 is C5-10-cycloalkyl o...

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Bibliographic Details
Main Authors LEROUX, FREDERIC, SCHLOSSER, MANFRED, METTLER, HANSPETER
Format Patent
LanguageEnglish
French
German
Published 26.11.2008
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula: wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally being substituted with one or more halogen atoms, and R2 and R3 are equal and are C5-10-cycloalkyl and C1-6-alkyl, or R2 is C5-10-cycloalkyl or C1-6-alkyl, and R3 is aryl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, nitro, amino, C1-6-alkyl, C1-6-akoxy and di-C1-6-alkylamino groups,2 and each C1-6-alkyl, C1-6-alkoxy, di-C1-6-alkylamino and C5-10-cycloalkyl group in R2 and R3 is optionally substituted with one or more halogen atoms, from 2,2',6,6'-tetrabromobiphenyl by a sequence of bromine-metal exchanges and subsequent reactions.
Bibliography:Application Number: EP20050756224