USE OF 4-HYDROXYTAMOXIFEN FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF GYNECOMASTIA
The present invention provides methods for treating and preventing gynecomastia by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts, 4-hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with gynecomast...
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| Main Authors | , |
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| Format | Patent |
| Language | English French German |
| Published |
30.08.2006
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides methods for treating and preventing gynecomastia by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts, 4-hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with gynecomastia, this reduces the effective estrogen-androgen ratio in the breast tissue, thereby reducing ductal proliferation, epithelial and stromal hyperplasia, and pain. In patients at risk for developing gynecomastia, 4-hydroxy tamoxifen's anti-estrogenic effect prevents tissue proliferation and its accompanying pain. |
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| AbstractList | The present invention provides methods for treating and preventing gynecomastia by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts, 4-hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with gynecomastia, this reduces the effective estrogen-androgen ratio in the breast tissue, thereby reducing ductal proliferation, epithelial and stromal hyperplasia, and pain. In patients at risk for developing gynecomastia, 4-hydroxy tamoxifen's anti-estrogenic effect prevents tissue proliferation and its accompanying pain. |
| Author | LE NESTOUR, ELISABETH PALUMBO, ANDREW, R |
| Author_xml | – fullname: LE NESTOUR, ELISABETH – fullname: PALUMBO, ANDREW, R |
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| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | UTILISATION DU 4-HYDROXYTAMOXIFÈNE DANS LA PRÉPARATION D'UN MÉDICAMENT DESTINÉ AU TRAITEMENT DE LA GYNÉCOMASTIE VERWENDUNG VON 4-HYDROXYTAMOXIFEN ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG VON GYNÄKOMASTIE |
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| Notes | Application Number: EP20040803913 |
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| RelatedCompanies | ASCEND THERAPEUTICS, INC LABORATOIRES BESINS INTERNATIONAL |
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| Snippet | The present invention provides methods for treating and preventing gynecomastia by administering 4-hydroxy tamoxifen to a patient. When percutaneously... |
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| SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | USE OF 4-HYDROXYTAMOXIFEN FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF GYNECOMASTIA |
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