Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions includ...

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Main Authors TRUJILLO, JOHN I, NEUMANN, WILLIAM L, ZENG, QUINGPING, HAYES, MICHAEL J, FENTON, RICK, WOOD, RHONDA, LINDMARK, RICHARD, DICE, TOM, PARLOW, JOHN J, CASE, BRENDA, REITZ, DAVID B, LONG, SCOTT A, WANG, CHINGNG, FRANKLIN, GARY W, JONES, DARIN E, HUANG, WEI, HUANG, HORNGIH, RUEPPEL, MELVIN L, KUSTURIN, CARRIE, SOUTH, MICHAEL S
Format Patent
LanguageEnglish
French
German
Published 19.10.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
AbstractList The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
Author WANG, CHINGNG
DICE, TOM
CASE, BRENDA
ZENG, QUINGPING
FRANKLIN, GARY W
HUANG, HORNGIH
SOUTH, MICHAEL S
HUANG, WEI
NEUMANN, WILLIAM L
PARLOW, JOHN J
JONES, DARIN E
HAYES, MICHAEL J
KUSTURIN, CARRIE
RUEPPEL, MELVIN L
LONG, SCOTT A
FENTON, RICK
LINDMARK, RICHARD
WOOD, RHONDA
REITZ, DAVID B
TRUJILLO, JOHN I
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– fullname: NEUMANN, WILLIAM L
– fullname: ZENG, QUINGPING
– fullname: HAYES, MICHAEL J
– fullname: FENTON, RICK
– fullname: WOOD, RHONDA
– fullname: LINDMARK, RICHARD
– fullname: DICE, TOM
– fullname: PARLOW, JOHN J
– fullname: CASE, BRENDA
– fullname: REITZ, DAVID B
– fullname: LONG, SCOTT A
– fullname: WANG, CHINGNG
– fullname: FRANKLIN, GARY W
– fullname: JONES, DARIN E
– fullname: HUANG, WEI
– fullname: HUANG, HORNGIH
– fullname: RUEPPEL, MELVIN L
– fullname: KUSTURIN, CARRIE
– fullname: SOUTH, MICHAEL S
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DocumentTitleAlternate Substituierte polycyclische aryl und heteroarylpyrazinone zur selektiven Hemmung von der Blutgerinnungskaskade
Pyrazinones d'hétéroaryle et d'aryle polycyclique substituées utiles à l'inhibition selective de la coagulation en cascade
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Snippet The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
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