Cyclic amine derivatives and their use as drugs

A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1 alpha and/or MCP-1 on targe...

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Main Authors MUROGA, YUMIKO, IMAI, MINORU, SHIOTA, TATSUKI, TAKENOUCHI, OSAMI, TEIG, STEVEN L, FURUYA, MONORU, SUDOH, MASAKI, ENDO, NORIAKI, HADA, TAKAHIKO, MORITA, TAKUYA, TARBY, CHRISTIN M, KATAOKA, KEN-ICHIRO, TSUTSUMI, TAKAHARU, MOREE, WILNA, SOGAWA, RYO
Format Patent
LanguageEnglish
French
German
Published 13.07.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1 alpha and/or MCP-1 on target cells, they may be useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
AbstractList A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1 alpha and/or MCP-1 on target cells, they may be useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
Author SHIOTA, TATSUKI
ENDO, NORIAKI
IMAI, MINORU
SOGAWA, RYO
TSUTSUMI, TAKAHARU
TEIG, STEVEN L
MOREE, WILNA
HADA, TAKAHIKO
TAKENOUCHI, OSAMI
MUROGA, YUMIKO
TARBY, CHRISTIN M
SUDOH, MASAKI
FURUYA, MONORU
KATAOKA, KEN-ICHIRO
MORITA, TAKUYA
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– fullname: SUDOH, MASAKI
– fullname: ENDO, NORIAKI
– fullname: HADA, TAKAHIKO
– fullname: MORITA, TAKUYA
– fullname: TARBY, CHRISTIN M
– fullname: KATAOKA, KEN-ICHIRO
– fullname: TSUTSUMI, TAKAHARU
– fullname: MOREE, WILNA
– fullname: SOGAWA, RYO
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DocumentTitleAlternate Dérivés d'amines cycliques et leur utilisation comme medicament
Zyklische Aminoderivate und ihre Verwendung als Arzneimittel
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Cyclic amine derivatives and their use as drugs
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