METHODS FOR CONSTRUCTION AND SCREENING OF LIBRARIES OF CHEMOKINE VARIANTS

• Main Authors: HARTLEY, OLIVER, DORGHAM, KARIM, DEBRE, PATRICE, GOROCHOV, GUY, OFFORD, ROBIN
• Format: Patent
• Language: English; French; German
• Published: 14.02.2007
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist...