METHODS FOR CONSTRUCTION AND SCREENING OF LIBRARIES OF CHEMOKINE VARIANTS
The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | English French German |
| Published |
14.02.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases. |
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| AbstractList | The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases. |
| Author | OFFORD, ROBIN DORGHAM, KARIM DEBRE, PATRICE GOROCHOV, GUY HARTLEY, OLIVER |
| Author_xml | – fullname: HARTLEY, OLIVER – fullname: DORGHAM, KARIM – fullname: DEBRE, PATRICE – fullname: GOROCHOV, GUY – fullname: OFFORD, ROBIN |
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| DocumentTitleAlternate | PROCEDES DE CONSTRUCTION ET DE CRIBLAGE DE BIBLIOTHEQUES DE VARIANTS DE CHIMIOKINES METHODEN FÜR DIE KONSTRUKTION UND SCREENING VON CHEMOKINE VARIANTEN |
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| RelatedCompanies | UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) |
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| Snippet | The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | METHODS FOR CONSTRUCTION AND SCREENING OF LIBRARIES OF CHEMOKINE VARIANTS |
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