2-ARACHIDONYLGLYCEROL (2-AG) - AN INHIBITOR OF TUMOR NECROSIS FACTOR -ALFA AND NEUROPROTECTOR OF BRAIN IN CLOSED HEAD INJURY
The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF-alpha), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditi...
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Main Authors | , , , , |
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Format | Patent |
Language | English French German |
Published |
29.09.2004
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF-alpha), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF-alpha and/or by radical oxygen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG. It comprises also the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications. |
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AbstractList | The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF-alpha), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF-alpha and/or by radical oxygen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG. It comprises also the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications. |
Author | MECHOULAM, RAPHAEL SHOHAMI, ESTHER PANIKASHVILI, DAVID GALLILY, RUTH BREUER, AVIVA |
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DocumentTitleAlternate | 2-ARACHIDONYLGLYCEROL (2-AG) : INHIBITEUR DE FACTEUR DE NECROSE DES TUMEURS-ALFA ET NEUROPROTECTEUR DU CERVEAU DANS LES CAS DE BLESSURES FERMEES A LA TETE 2-ARACHIDONYLGLYCEROL, EIN HEMMER DES TUMOR NEKROSE FAKTORS -ALFA UND NEUROPROTEKTOR DES GEHIRNS BEI GESCHLOSSENEN KOPFVERLETZUNGEN |
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Snippet | The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF-alpha), in the reduction of edema caused... |
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Title | 2-ARACHIDONYLGLYCEROL (2-AG) - AN INHIBITOR OF TUMOR NECROSIS FACTOR -ALFA AND NEUROPROTECTOR OF BRAIN IN CLOSED HEAD INJURY |
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