NOVEL INDOLE DERIVATIVES EXHIBITING CHYMASE-INHIBITORY ACTIVITIES AND PROCESS FOR PREPARATION THEREOF

• Main Authors: TAKEYASU, TAKUMI, SHIOKAWA, SOJIRO, KASAI, HIDENORI, HARIMAYA, KENZO, YANAGISAWA, YUMIKO, TAKENOUCHI, OSAMI, YAMAMOTO, YASUO
• Format: Patent
• Language: English; French; German
• Published: 16.11.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R and R each stand for a hydrogen atom or an alkyl group, independently, or (ii) R and R as taken together form a cycloalkyl group or an aromatic ring, or (iii) R and R as taken together form a heterocyclic ring, and R is a hydrogen atom, a (C1-C10)alkyl group or others, R is a substituted alkyl group and R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.