Fused tricyclic analogues of guanosine for treating tumors

Fused tri-heterocyclic compounds of formula: R1 is H or alkyl; R2 is H, alkyl, alkenyl, aryl, heteroaryl, cyclyl, or heterocyclyl; R3 and R4, independently, is H, alkyl, alkenyl, aryl, heteroaryl, cyclyl, heterocyclyl, or (CRR)mX(CRR)nY; in which X is a bond, O, S, or NR; Y is alkoxy, aryloxy, heter...

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Main Authors YONG, MA WEI, LEE, FANG YU, LEE, FANG CHEN, YE, WU QIU, HUA, XIAO XU, YANG, CHANG AN, WU, XU AI
Format Patent
LanguageEnglish
French
German
Published 12.07.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Fused tri-heterocyclic compounds of formula: R1 is H or alkyl; R2 is H, alkyl, alkenyl, aryl, heteroaryl, cyclyl, or heterocyclyl; R3 and R4, independently, is H, alkyl, alkenyl, aryl, heteroaryl, cyclyl, heterocyclyl, or (CRR)mX(CRR)nY; in which X is a bond, O, S, or NR; Y is alkoxy, aryloxy, heteroaryloxy, OC(O)R, C(O)R, N(RR'), NRC(O)R', S(O)2R, or SR; each of m and n, independently, is 1, 2, 3, 4, or 5; each of R, R, R, R, R, and R<e'>, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and R5 is H or halogen.
Bibliography:Application Number: EP20020011934