Intermediates for preparing the R or S enantiomer of 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl -amino]-propan-2-ol[carvedilol]

The subject matter of the invention are R-(+)-1-ÄN--äbenzylü-2'-(ä2''--phenoxy)-ethylü-aminoÜ-3--Ä9'''H-carbazol-4'''-yloxyÜ-propan-2-ol and S-(-)-1-ÄN--äbenzylü-2'-(ä2''--phenoxy)-ethylü-aminoÜ-3--Ä9'''H-carbazol-4'...

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Main Authors SIMIG, GYULA, CSELENYAK, JUDIT, DOMAN, IMRE, NAGY, PETER KOTAY, SZABO, TIBOR, SERES, PETER, RATKAI, ZOLTAN, BALAZS, LASZLO, NEMETH, NORBERT, NAGY, KALMAN, GREGOR, TAMAS, GREFF, ZOLTAN, BARKOCZY, JOZSEF, VERECZKEY, GYOERGYI DONATH
Format Patent
LanguageEnglish
French
German
Published 22.10.2003
Edition7
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Summary:The subject matter of the invention are R-(+)-1-ÄN--äbenzylü-2'-(ä2''--phenoxy)-ethylü-aminoÜ-3--Ä9'''H-carbazol-4'''-yloxyÜ-propan-2-ol and S-(-)-1-ÄN--äbenzylü-2'-(ä2''--phenoxy)-ethylü-aminoÜ-3--Ä9'''H-carbazol-4'''-yloxyÜ-propan-2-ol and acid addition salts thereof. Via these intermediates the end products R and S enantiomers of 1-Ä9'H-carbazol-4'-yloxyÜ-3-Ää2''-(2'''---phenoxy)-ethylü-aminoÜ-propan-2-ol ÄcarvedilolÜ can be prepared in a very high purity simply and economically in high yields.
Bibliography:Application Number: EP20010111214