NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES

• Main Authors: GRIFFIN, JOHN, H, EASTMAN, DONNA, JACOBSEN, JOHN, R
• Format: Patent
• Language: English; French; German
• Published: 28.03.2001
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

This invention relates to novel multibinding compounds that bind to potassium (K<+>) channels and modulate their activity. The compounds of this invention comprise 2-10 K<+> channel ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlink...