LIGANDS FOR DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASES AND COMPLEXES THEREOF
Members of the collagen family are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Collagen directly interacts with the extracellular domains and evokes tyrosine phosphorylation of DDRs in a time and concentration dependent manner. Collagen activation of DDR1 induced phosp...
Saved in:
Main Authors | , |
---|---|
Format | Patent |
Language | English French German |
Published |
05.07.2000
|
Edition | 7 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Members of the collagen family are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Collagen directly interacts with the extracellular domains and evokes tyrosine phosphorylation of DDRs in a time and concentration dependent manner. Collagen activation of DDR1 induced phosphorylation of a docking site for the Shc phosphotyrosine binding domain. Therefore, isolated complexes are described comprising (a) a discoidin domain receptor tyrosine kinase or a part thereof, and a collagen or a part thereof; or (b) a discoidin domain receptor tyrosine kinase or a part thereof and Shc or PTB binding domain of Shc or a protein containing a PDZ domain or a PDZ domain. Compositions, methods, and uses are also described based on the interaction of DDRs with collagens. |
---|---|
AbstractList | Members of the collagen family are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Collagen directly interacts with the extracellular domains and evokes tyrosine phosphorylation of DDRs in a time and concentration dependent manner. Collagen activation of DDR1 induced phosphorylation of a docking site for the Shc phosphotyrosine binding domain. Therefore, isolated complexes are described comprising (a) a discoidin domain receptor tyrosine kinase or a part thereof, and a collagen or a part thereof; or (b) a discoidin domain receptor tyrosine kinase or a part thereof and Shc or PTB binding domain of Shc or a protein containing a PDZ domain or a PDZ domain. Compositions, methods, and uses are also described based on the interaction of DDRs with collagens. |
Author | PAWSON, ANTHONY VOGEL, WOLFGANG |
Author_xml | – fullname: VOGEL, WOLFGANG – fullname: PAWSON, ANTHONY |
BookMark | eNrjYmDJy89L5WTw8fF0d_RzCVZw8w9ScPEMdvb3dPH0U3Dx93UEUkGuzq4BIUCZkMgg_2BPP1cFb08_x2DXYAWgHgVnf98AH9cIIC_EwzXI1d-Nh4E1LTGnOJUXSnMzKLi5hjh76KYW5MenFhckJqfmpZbEuwYYGhiamliYOxoZE6EEAI45L2U |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences Physics |
DocumentTitleAlternate | LIGANDEN FÜR TYROSINKINASEN DES DISCOIDIN-DOMÄNE-REZEPTORS SOWIE KOMPLEXE DAVON LIGANDS POUR TYROSINE-KINASES RECEPTRICES A DOMAINE DISCOIDINE, ET COMPLEXES LES COMPRENANT |
Edition | 7 |
ExternalDocumentID | EP1015487A2 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_EP1015487A23 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 15:59:55 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English French German |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_EP1015487A23 |
Notes | Application Number: EP19980902892 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000705&DB=EPODOC&CC=EP&NR=1015487A2 |
ParticipantIDs | epo_espacenet_EP1015487A2 |
PublicationCentury | 2000 |
PublicationDate | 20000705 |
PublicationDateYYYYMMDD | 2000-07-05 |
PublicationDate_xml | – month: 07 year: 2000 text: 20000705 day: 05 |
PublicationDecade | 2000 |
PublicationYear | 2000 |
RelatedCompanies | MOUNT SINAI HOSPITAL CORPORATION |
RelatedCompanies_xml | – name: MOUNT SINAI HOSPITAL CORPORATION |
Score | 2.517458 |
Snippet | Members of the collagen family are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Collagen directly interacts with the... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
Title | LIGANDS FOR DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASES AND COMPLEXES THEREOF |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000705&DB=EPODOC&locale=&CC=EP&NR=1015487A2 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV07T8MwED5V5blBAVFe8oCyRVCaRxkqlNoOCaJxlAZUpip2UqlLWtEg_j4X0xYWmOLYsmVburvvs-_OANcIOnuyaykTTUdmWm53amYd5Zi2Kzv5tIMQWmlvi8gJXqynsT1uwGwdC6PzhH7q5IgoUQrlvdL6evFziMW0b-XyRs6wav7gp31mrNlxnb3GNtigz2PBBDUoxZIRJYh1NTb3UFtvIYp2a2Hgr4M6KGXx26L4B7Ad42BldQiNomzBHl0_vNaC3eHqvrsFO9pBUy2xciWEyyNA-v3oRWxEkMARFo6oCFkYESaGHn4STnmcYkv6loj6TQ2CBN1DrUmwD6FiGD_zMf6lAU-48I-B-DylgYkTnGw2Y8LjzVK6J9As52VxCkTKXi5lZrl2oWoKIrPMubuXynGQ0uXFtA3tP4c5-6ftHPa_Y89d89a-gGb1_lFcohWu5JXevy_PWYVH |
link.rule.ids | 230,309,783,888,25576,76876 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NT8IwFH8h-IE3RY342YPZbVFkH3ggZrSdm7J1GdPgiaxjJFwGkRn_fd8qoBc9rWvTpm3y3vv92vdeAa4RdHZlx8h0NB2pbtidqZ62M0s3bdmeTNsIoTPlbRFa3ovxNDJHNZitY2FUntBPlRwRJSpDeS-Vvl78HGIx5Vu5vJEzrJo_uEmPaWt2XGWvMTXW7_FIMEE1SrGkhTFiXYXNHdTWW4iw7UoY-Gu_CkpZ_LYo7j5sRzhYUR5ALS-a0KDrh9easBus7rubsKMcNLMlVq6EcHkISL8fnZANCRI4wvwhFT7zQ8JE4OAn5pRHCbYkb7Go3tQgSNAd1JoE-xAqgmjAR_iXeDzmwj0C4vKEejpOcLzZjDGPNkvpHEO9mBf5CRApuxMpU8M286yiIDJNrbt7mVkWUrpJPm1B689hTv9pu4KGlwSD8cAPn89g7zsO3dZvzXOol-8f-QVa5FJeqr38Ajv8iDo |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=LIGANDS+FOR+DISCOIDIN+DOMAIN+RECEPTOR+TYROSINE+KINASES+AND+COMPLEXES+THEREOF&rft.inventor=VOGEL%2C+WOLFGANG&rft.inventor=PAWSON%2C+ANTHONY&rft.date=2000-07-05&rft.externalDBID=A2&rft.externalDocID=EP1015487A2 |