CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by a diamine linker between the oligopeptide...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French German |
| Published |
17.12.2003
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| Edition | 7 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by a diamine linker between the oligopeptide and vinblastine. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH). |
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| AbstractList | Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by a diamine linker between the oligopeptide and vinblastine. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH). |
| Author | BRADY, STEPHEN, F GARSKY, VICTOR, M PAWLUCZYK, JOSEPH, M |
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| DocumentTitleAlternate | KONJUGATE WELCHE BEI DER BEHANDLUNG VON PROSTATAKREBS NÜTZLICH SIND CONJUGUES UTILES DANS LE TRAITEMENT DU CANCER DE LA PROSTATE |
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| RelatedCompanies | MERCK & CO., INC |
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| Snippet | Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen... |
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| Title | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER |
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