HIGH-SPEED LIQUID DEPOSITION DEVICE FOR BIOLOGICAL MOLECULE ARRAY FORMATION

• Main Authors: JOHNSTON, RICHARD, F, ROACH, DAVID, J
• Format: Patent
• Language: English; French; German
• Published: 12.04.2000
• Edition: 7
• Subjects: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; CHEMISTRY; COMBINATORIAL CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEASURING; METALLURGY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; TESTING; TRANSPORTING

A microspot deposition system featuring a hollow cylindrical wall extending from a closed end, terminating in an open end and including a longitudinal gap extending from the open end toward the closed end to allow the rapid exhaustion of the atmosphere and efficient cleaning within the cylindrical wall. The cylindrical wall defines a lumen with both the lumen and the gap adapted to facilitate capillary action of liquid in fluid communication therewith to form a meniscus proximate to the open end. To facilitate deposition of liquid contained within the lumen, the gap may be tapered so that it is narrowest proximate to the open end. The narrowed portion of the gap results in a meniscus having a reduced area to ensure preferential fluid flow toward the open end, which facilitates deposition via capillary action between the liquid in the lumen and a working surface on which the liquid is to be deposited.